Exercise dose-response of the V(E)/VCO(2) slope in postmenopausal women in the DREW study.

نویسندگان

  • Stephanie A Anaya
  • Timothy S Church
  • Steven N Blair
  • Jonathan N Myers
  • Conrad P Earnest
چکیده

PURPOSE Being overweight/obese, having hypertension, and being postmenopausal are risk factors for the development of congestive heart failure (CHF). A characteristic of CHF is an abnormal V(E)/VCO(2) slope, which is predictive of mortality in patients with CHF. Although the V(E)/VCO(2) slope is well established in CHF patients, little is known regarding interventions for "at-risk" populations. METHODS We examined the V(E)/VCO(2) slope in 401 sedentary, overweight, moderately hypertensive women randomized to 6 m of nonexercise (control) or 4 kcal x kg(-1) x wk(-1) (KKW), 8 KKW, or 12 KKW of exercise at an intensity corresponding to 50% of baseline VO(2max). We examined trends in exercise treatment dose versus change in mean V(E)/VCO(2) slope using a linear regression model (KKW vs V(E)/VCO(2) slope) and a linear mixed model. RESULTS Regression analysis showed a significant trend for a reduction in the V(E)/VCO(2) slope from baseline (mean +/- SD: 32.6 +/- 6.3; P < 0.004). When expressed as mean change (95% confidence interval (CI)) from baseline, we observed significant reductions in the V(E)/VCO(2) slope for the 8-KKW (-1.14; 95% CI, -1.5 to -0.2) and 12-KKW (-1.67; 95% CI, -2.3 to -0.3) groups. No significant effect was noted for the 4-KKW (-0.4; 95% CI, -1.2 to 0.15) group. CONCLUSION Moderate-intensity aerobic exercise at doses of 8 KKW or greater seems to present an adequate dose of exercise to promote small but significant reductions in the V(E)/VCO(2) slope in postmenopausal women who exhibit risk factors associated with the development of CHF.

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عنوان ژورنال:
  • Medicine and science in sports and exercise

دوره 41 5  شماره 

صفحات  -

تاریخ انتشار 2009